Attacking pain at its source: new perspectives on opioids
Nature medicine, 2003•nature.com
The treatment of severe pain with opioids has thus far been limited by their unwanted central
side effects. Recent research promises new approaches, including opioid analgesics acting
outside the central nervous system, targeting of opioid peptide–containing immune cells to
peripheral damaged tissue, and gene transfer to enhance opioid production at sites of injury.
side effects. Recent research promises new approaches, including opioid analgesics acting
outside the central nervous system, targeting of opioid peptide–containing immune cells to
peripheral damaged tissue, and gene transfer to enhance opioid production at sites of injury.
Abstract
The treatment of severe pain with opioids has thus far been limited by their unwanted central side effects. Recent research promises new approaches, including opioid analgesics acting outside the central nervous system, targeting of opioid peptide–containing immune cells to peripheral damaged tissue, and gene transfer to enhance opioid production at sites of injury.
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