[HTML][HTML] The regulator of G protein signaling RGS4 selectively enhances α2A-adreoreceptor stimulation of the GTPase activity of Go1α and Gi2α
A Cavalli, KM Druey, G Milligan - Journal of Biological Chemistry, 2000 - ASBMB
Agonist-stimulated high affinity GTPase activity of fusion proteins between the α 2A-
adrenoreceptor and the α subunits of forms of the G proteins G i1, G i2, G i3, and G o1,
modified to render them insensitive to the action of pertussis toxin, was measured following
transient expression in COS-7 cells. Addition of a recombinant regulator of G protein
signaling protein, RGS4, did not significantly affect basal GTPase activity nor agonist
stimulation of the fusion proteins containing Gα i1 and Gα i3 but markedly enhanced agonist …
adrenoreceptor and the α subunits of forms of the G proteins G i1, G i2, G i3, and G o1,
modified to render them insensitive to the action of pertussis toxin, was measured following
transient expression in COS-7 cells. Addition of a recombinant regulator of G protein
signaling protein, RGS4, did not significantly affect basal GTPase activity nor agonist
stimulation of the fusion proteins containing Gα i1 and Gα i3 but markedly enhanced agonist …