[HTML][HTML] Phosphorylation of SNAP-23 in activated human platelets
J Polgár, WS Lane, SH Chung, AK Houng… - Journal of Biological …, 2003 - ASBMB
Phosphorylation of SNARE proteins may provide a critical link between cell activation and
secretory processes. Platelets contain all three members of the SNAP-23/25/29 gene family,
but by comparison to brain tissue, SNAP-23 is the most highly enriched of these proteins in
platelets. SNAP-23 function is required for exocytosis from platelet α, dense, and lysosomal
granules. SNAP-23 was phosphorylated largely on serine residues in platelets activated
with thrombin. Phosphorylation kinetics paralleled or preceded granule secretion. Inhibition …
secretory processes. Platelets contain all three members of the SNAP-23/25/29 gene family,
but by comparison to brain tissue, SNAP-23 is the most highly enriched of these proteins in
platelets. SNAP-23 function is required for exocytosis from platelet α, dense, and lysosomal
granules. SNAP-23 was phosphorylated largely on serine residues in platelets activated
with thrombin. Phosphorylation kinetics paralleled or preceded granule secretion. Inhibition …