[HTML][HTML] Regulation of outside-in signaling in platelets by integrin-associated protein kinase Cβ

CS Buensuceso, A Obergfell, A Soriani, K Eto… - Journal of Biological …, 2005 - ASBMB
Studies with inhibitors have implicated protein kinase C (PKC) in the adhesive functions of
integrin α IIb β 3 in platelets, but the responsible PKC isoforms and mechanisms are
unknown. α IIb β 3 interacts directly with tyrosine kinases c-Src and Syk. Therefore, we
asked whether α IIb β 3 might also interact with PKC. Of the several PKC isoforms expressed
in platelets, only PKCβ co-immunoprecipitated with α IIb β 3 in response to the interaction of
platelets with soluble or immobilized fibrinogen. PKCβ recruitment to α IIb β 3 was …