[HTML][HTML] A role for PKCθ in outside‐in αIIbβ3 signaling
A Soriani, B Moran, M De Virgilio, T Kawakami… - Journal of Thrombosis …, 2006 - Elsevier
Fibrinogen binding to platelets triggers α IIb β 3‐dependent outside‐in signals that promote
actin rearrangements and cell spreading. Studies with chemical inhibitors or activators have
implicated protein kinase C (PKC) in α IIb β 3 function. However, the role of individual PKC
isoforms is poorly understood. Biochemical and genetic approaches were used to determine
whether PKCθ is involved in α IIb β 3 signaling. PKCθ was constitutively associated with α
IIb β 3 in human and murine platelets. Fibrinogen binding to α IIb β 3 stimulated the …
actin rearrangements and cell spreading. Studies with chemical inhibitors or activators have
implicated protein kinase C (PKC) in α IIb β 3 function. However, the role of individual PKC
isoforms is poorly understood. Biochemical and genetic approaches were used to determine
whether PKCθ is involved in α IIb β 3 signaling. PKCθ was constitutively associated with α
IIb β 3 in human and murine platelets. Fibrinogen binding to α IIb β 3 stimulated the …