[HTML][HTML] Structural basis of constitutive activity and a unique nucleotide binding mode of human Pim-1 kinase
Pim-1 kinase is a member of a distinct class of serine/threonine kinases consisting of Pim-1,
Pim-2, and Pim-3. Pim kinases are highly homologous to one another and share a unique
consensus hinge region sequence, ER-PXPX, with its two proline residues separated by a
non-conserved residue, but they (Pim kinases) have< 30% sequence identity with other
kinases. Pim-1 has been implicated in both cytokine-induced signal transduction and the
development of lymphoid malignancies. We have determined the crystal structures of apo …
Pim-2, and Pim-3. Pim kinases are highly homologous to one another and share a unique
consensus hinge region sequence, ER-PXPX, with its two proline residues separated by a
non-conserved residue, but they (Pim kinases) have< 30% sequence identity with other
kinases. Pim-1 has been implicated in both cytokine-induced signal transduction and the
development of lymphoid malignancies. We have determined the crystal structures of apo …