[HTML][HTML] The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death
B Yan, M Zemskova, S Holder, V Chin, A Kraft… - Journal of Biological …, 2003 - ASBMB
Hematopoietic growth factors mediate the survival and proliferation of blood-forming cells,
but the mechanisms through which these proteins produce their effects are incompletely
known. Recent studies have identified the pim family of kinases as mediators of cytokine-
dependent survival signals. Several studies have identified substrates for the pim-1 kinase,
but little is known about the other family members, pim-2 and pim-3. We have investigated
potential functions for the pim-2 kinase in factor-dependent murine hematopoietic cells. We …
but the mechanisms through which these proteins produce their effects are incompletely
known. Recent studies have identified the pim family of kinases as mediators of cytokine-
dependent survival signals. Several studies have identified substrates for the pim-1 kinase,
but little is known about the other family members, pim-2 and pim-3. We have investigated
potential functions for the pim-2 kinase in factor-dependent murine hematopoietic cells. We …