Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of …

E Bonora, G Targher, M Alberiche… - Diabetes …, 2000 - Am Diabetes Assoc
E Bonora, G Targher, M Alberiche, RC Bonadonna, F Saggiani, MB Zenere, T Monauni…
Diabetes care, 2000Am Diabetes Assoc
OBJECTIVE: To evaluate whether the homeostasis model assessment (HOMA) is a reliable
surrogate measure of in vivo insulin sensitivity in humans. RESEARCH DESIGN AND
METHODS: In the present study, we compared insulin sensitivity as assessed by a 4-h
euglycemic (approximately 5 mmol/l) hyperinsulinemic (approximately 300 pmol/l) clamp
with HOMA in 115 subjects with various degrees of glucose tolerance and insulin sensitivity.
RESULTS: We found a strong correlation between clamp-measured total glucose disposal …
OBJECTIVE
To evaluate whether the homeostasis model assessment (HOMA) is a reliable surrogate measure of in vivo insulin sensitivity in humans.
RESEARCH DESIGN AND METHODS
In the present study, we compared insulin sensitivity as assessed by a 4-h euglycemic (approximately 5 mmol/l) hyperinsulinemic (approximately 300 pmol/l) clamp with HOMA in 115 subjects with various degrees of glucose tolerance and insulin sensitivity.
RESULTS
We found a strong correlation between clamp-measured total glucose disposal and HOMA-estimated insulin sensitivity (r = -0.820, P<0.0001), with no substantial differences between men (r = -0.800) and women (r = -0.796), younger (aged <50 years, r = -0.832) and older (r = -0.800) subjects, nonobese (BMI <27 kg/m2, r = -0.800) and obese (r = -0.765) subjects, nondiabetic (r = -0.754) and diabetic (r = -0.695) subjects, and normotensive ( r = -0.786) and hypertensive (r = -0.762) subjects. Also, we found good agreement between the two methods in the categorization of subjects according to insulin sensitivity (weighted k = 0.63).
CONCLUSIONS
We conclude that the HOMA can be reliably used in large-scale or epidemiological studies in which only a fasting blood sample is available to assess insulin sensitivity
Am Diabetes Assoc