An Extensive Class of Small RNAs in Caenorhabditis elegans
RC Lee, V Ambros - science, 2001 - science.org
RC Lee, V Ambros
science, 2001•science.orgThe lin-4 and let-7 antisense RNAs are temporal regulators that control the timing of
developmental events in Caenorhabditis elegans by inhibiting translation of target mRNAs.
let-7 RNA is conserved among bilaterian animals, suggesting that this class of small RNAs
[microRNAs (miRNAs)] is evolutionarily ancient. Using bioinformatics and cDNA cloning, we
found 15 new miRNA genes in C. elegans. Several of these genes express small transcripts
that vary in abundance during C. elegans larval development, and three of them have …
developmental events in Caenorhabditis elegans by inhibiting translation of target mRNAs.
let-7 RNA is conserved among bilaterian animals, suggesting that this class of small RNAs
[microRNAs (miRNAs)] is evolutionarily ancient. Using bioinformatics and cDNA cloning, we
found 15 new miRNA genes in C. elegans. Several of these genes express small transcripts
that vary in abundance during C. elegans larval development, and three of them have …
The lin-4 and let-7 antisense RNAs are temporal regulators that control the timing of developmental events inCaenorhabditis elegans by inhibiting translation of target mRNAs. let-7 RNA is conserved among bilaterian animals, suggesting that this class of small RNAs [microRNAs (miRNAs)] is evolutionarily ancient. Using bioinformatics and cDNA cloning, we found 15 new miRNA genes in C. elegans. Several of these genes express small transcripts that vary in abundance during C. elegans larval development, and three of them have apparent homologs in mammals and/or insects. Small noncoding RNAs of the miRNA class appear to be numerous and diverse.
AAAS