The mechanism of non-homologous end-joining: a synopsis of synapsis
E Weterings, DC Van Gent - DNA repair, 2004 - Elsevier
Repair of DNA double-strand breaks (DSBs) by non-homologous end-joining (NHEJ) is
required for resistance to genotoxic agents, such as ionizing radiation, but also for proper
development of the vertebrate immune system. Much progress has been made in identifying
the factors that are involved in this repair pathway. We are now entering the phase in which
we begin to understand basic concepts of the reaction mechanism and regulation of non-
homologous end-joining. This review concentrates on novel insights into damage …
required for resistance to genotoxic agents, such as ionizing radiation, but also for proper
development of the vertebrate immune system. Much progress has been made in identifying
the factors that are involved in this repair pathway. We are now entering the phase in which
we begin to understand basic concepts of the reaction mechanism and regulation of non-
homologous end-joining. This review concentrates on novel insights into damage …