[11] Patch-clamp studies of cystic fibrosis transmembrane conductance regulator chloride channel
JW Hanrahan, Z Kone, CJ Mathews, J Luo, Y Jia… - Methods in …, 1998 - Elsevier
Publisher Summary The cystic fibrosis transmembrane conductance regulator (CFTR) has
two sets of six membrane-spanning regions (TM1-TM12), two nucleotidebinding folds
(NBF1, NBF2), and a regulatory domain containing numerous potential sites for
phosphorylation by protein kinases. It belongs to an important superfamily of ATP-binding
cassette (ABC) transport proteins that has members in bacteria, yeast, and higher
eukaryotes. Although it may have multiple functions, it is generally accepted that CFTR …
two sets of six membrane-spanning regions (TM1-TM12), two nucleotidebinding folds
(NBF1, NBF2), and a regulatory domain containing numerous potential sites for
phosphorylation by protein kinases. It belongs to an important superfamily of ATP-binding
cassette (ABC) transport proteins that has members in bacteria, yeast, and higher
eukaryotes. Although it may have multiple functions, it is generally accepted that CFTR …