Rate of cell death in parkinsonism indicates active neuropathological process
PL McGeer, S Itagaki, H Akiyama… - Annals of Neurology …, 1988 - Wiley Online Library
PL McGeer, S Itagaki, H Akiyama, EG McGeer
Annals of Neurology: Official Journal of the American Neurological …, 1988•Wiley Online LibraryIt has been hypothesized that idiopathic parkinsonism might be due to age‐related attrition
of dopamine neurons occurring long after an initial acute episode. We present evidence
against this hypothesis, based on our finding of at least six times as many HLA‐DR—
positive microglia phagocytosing dopamine neurons in parkinsonian brains as in control
brains. This difference indicates an active pathological process.
of dopamine neurons occurring long after an initial acute episode. We present evidence
against this hypothesis, based on our finding of at least six times as many HLA‐DR—
positive microglia phagocytosing dopamine neurons in parkinsonian brains as in control
brains. This difference indicates an active pathological process.
Abstract
It has been hypothesized that idiopathic parkinsonism might be due to age‐related attrition of dopamine neurons occurring long after an initial acute episode. We present evidence against this hypothesis, based on our finding of at least six times as many HLA‐DR—positive microglia phagocytosing dopamine neurons in parkinsonian brains as in control brains. This difference indicates an active pathological process.
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