The neurotoxin MPTP causes degeneration of specific nucleus A8, A9 and A10 dopaminergic neurons in the mouse
DC German, EL Nelson, CL Liang, SG Speciale… - …, 1996 - Elsevier
The neurotoxin MPTP has been used to create an animal model of Parkinson's disease in
the mouse, in part, because it causes a significant loss of dopaminergic neurons in the
substantia nigra (nucleus A9). The purpose of the present study was to determine whether
MPTP also causes degeneration of midbrain dopaminergic neurons in nuclei A8 and A10 in
the mouse, as occurs in humans with Parkinson's disease. Two commonly used strains of
mice were used: FVB/N and C57BL/6. MPTP was administered in cumulative doses of 50 …
the mouse, in part, because it causes a significant loss of dopaminergic neurons in the
substantia nigra (nucleus A9). The purpose of the present study was to determine whether
MPTP also causes degeneration of midbrain dopaminergic neurons in nuclei A8 and A10 in
the mouse, as occurs in humans with Parkinson's disease. Two commonly used strains of
mice were used: FVB/N and C57BL/6. MPTP was administered in cumulative doses of 50 …