Occurrence of T cells in the brain of Alzheimer's disease and other neurological diseases

T Togo, H Akiyama, E Iseki, H Kondo, K Ikeda… - Journal of …, 2002 - Elsevier
We investigated the occurrence of T cells in the brain parenchyma of Alzheimer's disease
(AD), non-AD degenerative dementias and controls by semi-quantitative analysis of
immunohistochemically stained tissue sections. In all cases, we found at least some T cells.
The number of T cells was increased in the majority of AD cases compared with other cases.
The phenotype of T cells in the AD brain indicates that they are activated but are not fully
differentiated. Antigen-triggered clonal expansion is not likely to take place. Local …