Biomarkers of endothelial dysfunction and risk of type 2 diabetes mellitus
JB Meigs, FB Hu, N Rifai, JAE Manson - Jama, 2004 - jamanetwork.com
ContextEndothelial dysfunction occurs in diagnosed type 2 diabetes mellitus but may also
precede development of diabetes. ObjectiveTo determine whether elevated plasma levels of
biomarkers reflecting endothelial dysfunction (E-selectin; intercellular adhesion molecule 1
[ICAM-1]; and vascular cell adhesion molecule 1 [VCAM-1]) predict development of type 2
diabetes in initially nondiabetic women. Design and SettingProspective, nested case-control
study within the Nurses' Health Study, an ongoing US study initiated in 1976. ParticipantsOf …
precede development of diabetes. ObjectiveTo determine whether elevated plasma levels of
biomarkers reflecting endothelial dysfunction (E-selectin; intercellular adhesion molecule 1
[ICAM-1]; and vascular cell adhesion molecule 1 [VCAM-1]) predict development of type 2
diabetes in initially nondiabetic women. Design and SettingProspective, nested case-control
study within the Nurses' Health Study, an ongoing US study initiated in 1976. ParticipantsOf …