Background Spreading depression of Leao has been hypothesized as the basis for the
visual aura of the migraine attack, supported by cerebral blood flow measurements of
spreading hypoperfusion. The early depolarizing or activation phase of experimental
spreading depression, however, is associated with a transient but pronounced cerebral
blood flow increase that precedes spreading hypoperfusion. Objective To study this early
phase of the migraine attack, we investigated visually triggered attacks of headache and …