Reduced threshold for cortical spreading depression in female mice
KC Brennan, M Romero‐Reyes… - Annals of Neurology …, 2007 - Wiley Online Library
Annals of Neurology: Official Journal of the American Neurological …, 2007•Wiley Online Library
The prevalence of migraine is much greater in female than male individuals. Cortical
spreading depression (CSD) is thought to be a fundamental mechanism of migraine, and
CSD in rodents is used as a model for migraine. We used optical intrinsic signal imaging
and electrophysiological techniques to investigate CSD in C57Bl/6 mice. Using two different
methods for induction of CSD, we found that female mice had a significantly reduced
threshold for induction of CSD compared with male mice. These results suggest an …
spreading depression (CSD) is thought to be a fundamental mechanism of migraine, and
CSD in rodents is used as a model for migraine. We used optical intrinsic signal imaging
and electrophysiological techniques to investigate CSD in C57Bl/6 mice. Using two different
methods for induction of CSD, we found that female mice had a significantly reduced
threshold for induction of CSD compared with male mice. These results suggest an …
Abstract
The prevalence of migraine is much greater in female than male individuals. Cortical spreading depression (CSD) is thought to be a fundamental mechanism of migraine, and CSD in rodents is used as a model for migraine. We used optical intrinsic signal imaging and electrophysiological techniques to investigate CSD in C57Bl/6 mice. Using two different methods for induction of CSD, we found that female mice had a significantly reduced threshold for induction of CSD compared with male mice. These results suggest an increased cortical excitability in female mice that may be independent of the estrous cycle. Ann Neurol 2007
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