Migraine: gene mutations and functional consequences
AMJM van den Maagdenberg, J Haan… - Current opinion in …, 2007 - journals.lww.com
AMJM van den Maagdenberg, J Haan, GM Terwindt, MD Ferrari
Current opinion in neurology, 2007•journals.lww.comIdentification and analysis of gene mutations in familial hemiplegic migraine revealed a
major role for disturbed ion transport in this disorder. Cellular and transgenic mouse models
of familial hemiplegic migraine genes suggest that increased potassium and glutamate play
a role in the pathophysiology of the disorder. Despite progress, no genes have been
discovered for common migraine.
major role for disturbed ion transport in this disorder. Cellular and transgenic mouse models
of familial hemiplegic migraine genes suggest that increased potassium and glutamate play
a role in the pathophysiology of the disorder. Despite progress, no genes have been
discovered for common migraine.
Summary
Identification and analysis of gene mutations in familial hemiplegic migraine revealed a major role for disturbed ion transport in this disorder. Cellular and transgenic mouse models of familial hemiplegic migraine genes suggest that increased potassium and glutamate play a role in the pathophysiology of the disorder. Despite progress, no genes have been discovered for common migraine.
Lippincott Williams & Wilkins