Biochemistry and biology of ARHI (DIRAS3), an imprinted tumor suppressor gene whose expression is lost in ovarian and breast cancers
Y Yu, R Luo, Z Lu, WW Feng, D Badgwell, JP Issa… - Methods in …, 2006 - Elsevier
ARHI is a maternally imprinted tumor suppressor gene that is downregulated in 60% of
ovarian and breast cancers. Loss of ARHI expression is associated with tumor progression
in breast cancer and decreased disease‐free survival in ovarian cancer. ARHI encodes a 26‐
kDa protein with 55–62% homology to Ras and Rap. In contrast to Ras, ARHI inhibits
growth, motility, and invasion. ARHI contains a unique 34 amino‐acid extension at its N‐
terminus and differs from Ras in residues critical for GTPase activity and for its putative …
ovarian and breast cancers. Loss of ARHI expression is associated with tumor progression
in breast cancer and decreased disease‐free survival in ovarian cancer. ARHI encodes a 26‐
kDa protein with 55–62% homology to Ras and Rap. In contrast to Ras, ARHI inhibits
growth, motility, and invasion. ARHI contains a unique 34 amino‐acid extension at its N‐
terminus and differs from Ras in residues critical for GTPase activity and for its putative …