The synaptic Aβ hypothesis of Alzheimer disease
RE Tanzi - Nature neuroscience, 2005 - nature.com
Nature neuroscience, 2005•nature.com
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Aβ peptide is linked to Alzheimer pathology, but its toxic mechanism remains unclear. New work shows that Aβ leads to internalization of NMDA receptors, reducing their availability at synapses. The authors also suggest a molecular mechanism for this endocytosis.
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