[HTML][HTML] Structure of the C-domain of human cardiac troponin C in complex with the Ca2+ sensitizing drug EMD 57033
Ca 2+ binding to cardiac troponin C (cTnC) triggers contraction in heart muscle. In heart
failure, myofilaments response to Ca 2+ are often altered and compounds that sensitize the
myofilaments to Ca 2+ possess therapeutic value in this syndrome. One of the most potent
and selective Ca 2+ sensitizers is the thiadiazinone derivative EMD 57033, which increases
myocardial contractile function bothin vivo and in vitro and interacts with cTnCin vitro. We
have determined the NMR structure of the 1: 1 complex between Ca 2+-saturated C-domain …
failure, myofilaments response to Ca 2+ are often altered and compounds that sensitize the
myofilaments to Ca 2+ possess therapeutic value in this syndrome. One of the most potent
and selective Ca 2+ sensitizers is the thiadiazinone derivative EMD 57033, which increases
myocardial contractile function bothin vivo and in vitro and interacts with cTnCin vitro. We
have determined the NMR structure of the 1: 1 complex between Ca 2+-saturated C-domain …