Imaging the lungs in asthmatic patients by using hyperpolarized helium-3 magnetic resonance: assessment of response to methacholine and exercise challenge
S Samee, T Altes, P Powers, EE de Lange… - Journal of allergy and …, 2003 - Elsevier
Background: Imaging of gas distribution in the lungs of patients with asthma has been
restricted because of the lack of a suitable gaseous contrast agent. Hyperpolarized helium-3
(HHe3) provides a new technique for magnetic resonance imaging of lung diseases.
Objective: We sought to investigate the use of HHe3 gas to image the lungs of patients with
moderate or severe asthma and to assess changes in gas distribution after methacholine
and exercise challenge. Methods: Magnetic resonance imaging was performed in asthmatic …
restricted because of the lack of a suitable gaseous contrast agent. Hyperpolarized helium-3
(HHe3) provides a new technique for magnetic resonance imaging of lung diseases.
Objective: We sought to investigate the use of HHe3 gas to image the lungs of patients with
moderate or severe asthma and to assess changes in gas distribution after methacholine
and exercise challenge. Methods: Magnetic resonance imaging was performed in asthmatic …