Human immunodeficiency virus gp120 downregulates CD1d cell surface expression
CA Hage, LL Kohli, S Cho, RR Brutkiewicz… - Immunology letters, 2005 - Elsevier
CD1d is an MHC class I-like surface molecule that presents endogenous glycoplipid
antigens. The effect of HIV infection on CD1d surface expression has not yet been reported.
FACS analysis revealed significantly lower levels of CD1d on CD14+ monocytes from HIV-
infected subjects compared to HIV-infected subjects on HAART and healthy controls. CD1d
expression correlated inversely with viral load in infected individuals. CD1d surface
expression on human cell lines was downregulated after infection with M-tropic HIV, T-tropic …
antigens. The effect of HIV infection on CD1d surface expression has not yet been reported.
FACS analysis revealed significantly lower levels of CD1d on CD14+ monocytes from HIV-
infected subjects compared to HIV-infected subjects on HAART and healthy controls. CD1d
expression correlated inversely with viral load in infected individuals. CD1d surface
expression on human cell lines was downregulated after infection with M-tropic HIV, T-tropic …