Inhibition of CD1 Expression in Human Dendritic Cells during Intracellular Infection with Leishmania donovani
JL Amprey, GF Späth, SA Porcelli - Infection and immunity, 2004 - Am Soc Microbiol
JL Amprey, GF Späth, SA Porcelli
Infection and immunity, 2004•Am Soc MicrobiolDendritic cells can initiate antimicrobial responses by CD1-mediated presentation of
pathogen-derived glycolipids. We show that the protozoan Leishmania donovani inhibits
CD1 expression and prevents activation of CD1-restricted T cells by dendritic cells. Evasion
of presentation by CD1 may represent a Leishmania survival strategy to avoid recognition of
abundant parasite glycolipids.
pathogen-derived glycolipids. We show that the protozoan Leishmania donovani inhibits
CD1 expression and prevents activation of CD1-restricted T cells by dendritic cells. Evasion
of presentation by CD1 may represent a Leishmania survival strategy to avoid recognition of
abundant parasite glycolipids.
Abstract
Dendritic cells can initiate antimicrobial responses by CD1-mediated presentation of pathogen-derived glycolipids. We show that the protozoan Leishmania donovani inhibits CD1 expression and prevents activation of CD1-restricted T cells by dendritic cells. Evasion of presentation by CD1 may represent a Leishmania survival strategy to avoid recognition of abundant parasite glycolipids.
American Society for Microbiology