[HTML][HTML] Down-regulation of human DAB2IP gene expression mediated by polycomb Ezh2 complex and histone deacetylase in prostate cancer
H Chen, S Tu, JT Hsieh - Journal of Biological Chemistry, 2005 - ASBMB
Human DAB2IP (hDAB2IP), a novel GTPase-activating protein modulating the Ras-
mediated signaling and tumor necrosis factor-mediated apoptosis, is a potent growth
inhibitor in human prostate cancer (PCa). Loss of hDAB2IP expression in PCa is due to
altered epigenetic regulation (ie DNA methylation and histone modification) of its promoter
region. The elevated polycomb Ezh2, a histone methyltransferase, has been associated with
PCa progression. In this study, we have demonstrated that an increased Ezh2 expression in …
mediated signaling and tumor necrosis factor-mediated apoptosis, is a potent growth
inhibitor in human prostate cancer (PCa). Loss of hDAB2IP expression in PCa is due to
altered epigenetic regulation (ie DNA methylation and histone modification) of its promoter
region. The elevated polycomb Ezh2, a histone methyltransferase, has been associated with
PCa progression. In this study, we have demonstrated that an increased Ezh2 expression in …