[HTML][HTML] Hypoxia and inflammatory synovitis: observations and speculation.

CR Stevens, RB Williams, AJ Farrell… - Annals of the rheumatic …, 1991 - ncbi.nlm.nih.gov
CR Stevens, RB Williams, AJ Farrell, DR Blake
Annals of the rheumatic diseases, 1991ncbi.nlm.nih.gov
In recent years considerable research interest has been directed at studying the biological
consequences of tissue hypoxia. As this work progresses it becomes increasingly apparent
that tissue hypoxia has complex biological consequences. Much is now known about the
natural defences of the body to hypoxia, including heat shock protein synthesis and
angiogenesis. These systems are normally under rigid control, but this would seem not so in
the rheumatoid joint. This accumulation of knowledge has prompted the belated …
In recent years considerable research interest has been directed at studying the biological consequences of tissue hypoxia. As this work progresses it becomes increasingly apparent that tissue hypoxia has complex biological consequences. Much is now known about the natural defences of the body to hypoxia, including heat shock protein synthesis and angiogenesis. These systems are normally under rigid control, but this would seem not so in the rheumatoid joint. This accumulation of knowledge has prompted the belated reawakening of interest in joint hypoxia; it isnow clear that an understanding of the physiological and pathological effects of joint hypoxia is of great importanceto both clinical and research rheumatology. This review outlines joint hypoxia from a historical perspective and offers explanations for the phenomenon. Some of the more perti-nent implications of hypoxia in the context of inflammatory synovitis are discussed.
ncbi.nlm.nih.gov