[HTML][HTML] A TRP channel that senses cold stimuli and menthol
AM Peier, A Moqrich, AC Hergarden, AJ Reeve… - Cell, 2002 - cell.com
Cell, 2002•cell.com
A distinct subset of sensory neurons are thought to directly sense changes in thermal energy
through their termini in the skin. Very little is known about the molecules that mediate
thermoreception by these neurons. Vanilloid Receptor 1 (VR1), a member of the TRP family
of channels, is activated by noxious heat. Here we describe the cloning and characterization
of TRPM8, a distant relative of VR1. TRPM8 is specifically expressed in a subset of pain-and
temperature-sensing neurons. Cells overexpressing the TRPM8 channel can be activated …
through their termini in the skin. Very little is known about the molecules that mediate
thermoreception by these neurons. Vanilloid Receptor 1 (VR1), a member of the TRP family
of channels, is activated by noxious heat. Here we describe the cloning and characterization
of TRPM8, a distant relative of VR1. TRPM8 is specifically expressed in a subset of pain-and
temperature-sensing neurons. Cells overexpressing the TRPM8 channel can be activated …
Abstract
A distinct subset of sensory neurons are thought to directly sense changes in thermal energy through their termini in the skin. Very little is known about the molecules that mediate thermoreception by these neurons. Vanilloid Receptor 1 (VR1), a member of the TRP family of channels, is activated by noxious heat. Here we describe the cloning and characterization of TRPM8, a distant relative of VR1. TRPM8 is specifically expressed in a subset of pain- and temperature-sensing neurons. Cells overexpressing the TRPM8 channel can be activated by cold temperatures and by a cooling agent, menthol. Our identification of a cold-sensing TRP channel in a distinct subpopulation of sensory neurons implicates an expanded role for this family of ion channels in somatic sensory detection.
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