Hyperlipidemia and surfactants: the liver sieve is a link

VC Cogger, SN Hilmer, D Sullivan, M Muller, R Fraser… - Atherosclerosis, 2006 - Elsevier
Poloxamer 407 is a ubiquitous synthetic surfactant that causes massive hyperlipidemia and
atherosclerosis in the rodent. The initial step in hepatic metabolism of lipoproteins is their
transfer through 100–200nm pores (fenestrations) in the liver sinusoidal endothelial cell,
prior to receptor-mediated uptake. The 'liver sieve hypothesis' emphasizes the role of these
fenestrations in the regulation of lipoprotein disposition. Here we show that P407 causes
dramatic defenestration of the liver sinusoidal endothelium in vivo. By 24h after …