Dilated cardiomyopathy is characterized by ventricular dilation with systolic dysfunction of
cardiac muscle. Recent genetic studies have revealed that mutations in genes for
cytoskeleton proteins distributed in the Z-disc and/or intercalated discs of the cardiac muscle
are major predictors of cardiomyopathy. However, as mutations in these genes can account
for only a part of the patient population, there should be another disease-causing gene (s)
for cardiomyopathy. Cypher/ZASP appears to be an ideal candidate for the cardiomyopathy …