Phenotypic and functional maturation of tumor antigen-reactive CD8+ T lymphocytes in patients undergoing multiple course peptide vaccination

DJ Powell Jr, SA Rosenberg - Journal of immunotherapy, 2004 - journals.lww.com
Successful immunotherapy with peptide vaccines depends on the in vivo generation of
sufficient numbers of anti-tumor T cells with appropriate phenotypic and functional
characteristics to mediate tumor destruction. Herein, we report the induction of high
frequencies of circulating CD8+ T cells (4.8% to 38.1%) directed against the native gp100:
209-217 peptide derived from the gp100 melanoma-melanocyte tumor antigen in five HLA-
A* 0201 patients at high risk of recurrence of melanoma after multiple courses of …