Macrophage tumor killing: influence of the local environment
JB Hibbs Jr, RR Taintor, HA Chapman Jr, JB Weinberg - Science, 1977 - science.org
JB Hibbs Jr, RR Taintor, HA Chapman Jr, JB Weinberg
Science, 1977•science.orgTumor killing by activated macrophages is not a highly determined biologic event, but a
relative capability influenced by the local environment. An intrinsic macrophage cytotoxic
effector system is modulated by serum and other environmental factors that can either
enhance or suppress tumor killing. Activated macrophages kill tumor cells only when a
regulating threshold drops to a critically low level.
relative capability influenced by the local environment. An intrinsic macrophage cytotoxic
effector system is modulated by serum and other environmental factors that can either
enhance or suppress tumor killing. Activated macrophages kill tumor cells only when a
regulating threshold drops to a critically low level.
Tumor killing by activated macrophages is not a highly determined biologic event, but a relative capability influenced by the local environment. An intrinsic macrophage cytotoxic effector system is modulated by serum and other environmental factors that can either enhance or suppress tumor killing. Activated macrophages kill tumor cells only when a regulating threshold drops to a critically low level.
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