Efficacy of soluble IL-4 receptor for the treatment of adults with asthma
LC Borish, HS Nelson, J Corren, G Bensch… - Journal of Allergy and …, 2001 - Elsevier
Background: IL-4 mediates important proinflammatory functions in asthma, including
induction of the IgE isotype switch, increased expression of vascular cell adhesion molecule
1 and promotion of eosinophil transmigration across the endothelium, stimulation of mucus
production, and TH2 lymphocyte differentiation, leading to release of IL-4, IL-5, IL-9, and IL-
13. Objective: The current study evaluated the therapeutic potential of inhaled recombinant
human soluble interleukin-4 receptor (IL-4R) as an IL-4 antagonist. Methods: This study was …
induction of the IgE isotype switch, increased expression of vascular cell adhesion molecule
1 and promotion of eosinophil transmigration across the endothelium, stimulation of mucus
production, and TH2 lymphocyte differentiation, leading to release of IL-4, IL-5, IL-9, and IL-
13. Objective: The current study evaluated the therapeutic potential of inhaled recombinant
human soluble interleukin-4 receptor (IL-4R) as an IL-4 antagonist. Methods: This study was …