[HTML][HTML] PAWP, a Sperm-specific WW Domain-binding Protein, Promotes Meiotic Resumption and Pronuclear Development during Fertilization*♦
ATH Wu, P Sutovsky, G Manandhar, W Xu… - Journal of Biological …, 2007 - ASBMB
We report a novel alkaline extractable protein of the sperm head that exclusively resides in
the post-acrosomal sheath region of the perinuclear theca (PT) and is expressed and
assembled in elongating spermatids. It is a protein that shares sequence homology to the N-
terminal half of WW domain-binding protein 2, while the C-terminal half is unique and rich in
proline. A functional PPXY consensus binding site for group-I WW domain-containing
proteins, and numerous unique repeating motifs, YGXPPXG, are identified in the proline-rich …
the post-acrosomal sheath region of the perinuclear theca (PT) and is expressed and
assembled in elongating spermatids. It is a protein that shares sequence homology to the N-
terminal half of WW domain-binding protein 2, while the C-terminal half is unique and rich in
proline. A functional PPXY consensus binding site for group-I WW domain-containing
proteins, and numerous unique repeating motifs, YGXPPXG, are identified in the proline-rich …