[HTML][HTML] HLH106, a Drosophilasterol regulatory element-binding protein in a natural cholesterol auxotroph
JM Rosenfeld, TF Osborne - Journal of Biological Chemistry, 1998 - ASBMB
In mammalian cells, sterol regulatory element-binding proteins (SREBPs) coordinate
metabolic flux through the cholesterol and fatty acid biosynthetic pathways in response to
intracellular cholesterol levels. We describe experiments that evaluate the functional
equivalence of mammalian SREBPs and the insect homologue of SREBP-1a, HLH106, in
both mammalian and insect cell culture systems. HLH106 binds to both palindromic E-boxes
and direct repeat sterol regulatory elements (SREs) efficiently, suggesting that it has a dual …
metabolic flux through the cholesterol and fatty acid biosynthetic pathways in response to
intracellular cholesterol levels. We describe experiments that evaluate the functional
equivalence of mammalian SREBPs and the insect homologue of SREBP-1a, HLH106, in
both mammalian and insect cell culture systems. HLH106 binds to both palindromic E-boxes
and direct repeat sterol regulatory elements (SREs) efficiently, suggesting that it has a dual …