[HTML][HTML] Selective binding of sterol regulatory element-binding protein isoforms and co-regulatory proteins to promoters for lipid metabolic genes in liver
MK Bennett, YK Seo, S Datta, DJ Shin… - Journal of biological …, 2008 - ASBMB
Mice were subjected to different dietary manipulations to selectively alter expression of
hepatic sterol regulatory element-binding protein 1 (SREBP-1) or SREBP-2. mRNA levels for
key target genes were measured and compared with the direct binding of SREBP-1 and-2 to
the associated promoters using isoform specific antibodies in chromatin
immunoprecipitation studies. A diet supplemented with Zetia (ezetimibe) and lovastatin
increased and decreased nuclear SREBP-2 and SREBP-1, respectively, whereas a …
hepatic sterol regulatory element-binding protein 1 (SREBP-1) or SREBP-2. mRNA levels for
key target genes were measured and compared with the direct binding of SREBP-1 and-2 to
the associated promoters using isoform specific antibodies in chromatin
immunoprecipitation studies. A diet supplemented with Zetia (ezetimibe) and lovastatin
increased and decreased nuclear SREBP-2 and SREBP-1, respectively, whereas a …