[HTML][HTML] Glycogen synthase kinase 3β regulates GATA4 in cardiac myocytes
C Morisco, K Seta, SE Hardt, Y Lee, SF Vatner… - Journal of Biological …, 2001 - ASBMB
Inactivation of glycogen synthase kinase 3β (GSK3β) is critical for transcription of atrial
natriuretic factor (ANF) by β-adrenergic receptors in cardiac myocytes. We examined the
mechanism by which GSK3β regulates ANF transcription. Stimulation of β-adrenergic
receptors induced nuclear accumulation of GATA4, whereas β-adrenergic ANF transcription
was suppressed by dominant negative GATA4, suggesting that GATA4 plays an important
role in β-adrenergic ANF transcription. Interestingly, GATA4-mediated transcription was …
natriuretic factor (ANF) by β-adrenergic receptors in cardiac myocytes. We examined the
mechanism by which GSK3β regulates ANF transcription. Stimulation of β-adrenergic
receptors induced nuclear accumulation of GATA4, whereas β-adrenergic ANF transcription
was suppressed by dominant negative GATA4, suggesting that GATA4 plays an important
role in β-adrenergic ANF transcription. Interestingly, GATA4-mediated transcription was …