Toll-like receptor 9 contributes to recognition of Mycobacterium bovis Bacillus Calmette-Guerin by Flt3-ligand generated dendritic cells
F Von Meyenn, M Schaefer, H Weighardt, S Bauer… - Immunobiology, 2006 - Elsevier
Recognition of mycobacteria by the innate immune system is essential for the development
of an adaptive immune response. Mycobacterial antigens stimulate antigen presenting cells
(APCs) through distinct Toll-like receptors (TLRs) resulting in rapid activation of the innate
immune system. The role of TLRs during infection with Mycobacterium bovis Bacillus
Calmette-Guérin (BCG) has been evaluated for TLR2 and TLR4 only. Surprisingly, despite
the fact that immune stimulatory CpG-motifs have been originally derived from BCG, for the …
of an adaptive immune response. Mycobacterial antigens stimulate antigen presenting cells
(APCs) through distinct Toll-like receptors (TLRs) resulting in rapid activation of the innate
immune system. The role of TLRs during infection with Mycobacterium bovis Bacillus
Calmette-Guérin (BCG) has been evaluated for TLR2 and TLR4 only. Surprisingly, despite
the fact that immune stimulatory CpG-motifs have been originally derived from BCG, for the …