Oxysterols and atherosclerosis

AJ Brown, W Jessup - Atherosclerosis, 1999 - Elsevier
Oxysterols are present in human atherosclerotic plaque and are suggested to play an active
role in plaque development. Moreover, the oxysterol: cholesterol ratio in plaque is much
higher than in normal tissues or plasma. Oxysterols in plaque are derived both non-
enzymically, either from the diet and/or from in vivo oxidation, or (eg 27-hydroxycholesterol)
are formed enzymically during cholesterol catabolism. While undergoing many of the same
reactions as cholesterol, such as being esterified by cells and in plasma, certain oxysterols …