Inhibition of endothelium-dependent arterial relaxation by oxidized phosphatidylcholine
Y Rikitake, K Hirata, S Kawashima, N Inoue, H Akita… - Atherosclerosis, 2000 - Elsevier
Formation of oxidized phosphatidylcholine (ox-PC), oxidatively fragmented
phosphatidylcholine (PC) containing a short-chain and/or polar oxidative residue at the sn-2
position, in the process of LDL oxidation as well as its existence in atherosclerotic lesions
has been demonstrated. To clarify the pathophysiological role of ox-PC in the vascular
reactivity, we investigated the effects of various ox-PCs on the isometric tensions in rabbit
thoracic aortas. Ox-PCs, which were produced upon oxidation of sn-2 polyunsaturated fatty …
phosphatidylcholine (PC) containing a short-chain and/or polar oxidative residue at the sn-2
position, in the process of LDL oxidation as well as its existence in atherosclerotic lesions
has been demonstrated. To clarify the pathophysiological role of ox-PC in the vascular
reactivity, we investigated the effects of various ox-PCs on the isometric tensions in rabbit
thoracic aortas. Ox-PCs, which were produced upon oxidation of sn-2 polyunsaturated fatty …