High density lipoproteins in the intersection of diabetes mellitus, inflammation and cardiovascular disease
L Rohrer, M Hersberger… - Current opinion in …, 2004 - journals.lww.com
L Rohrer, M Hersberger, A von Eckardstein
Current opinion in lipidology, 2004•journals.lww.comThe protective properties of HDL in cytokine production, lipid oxidation, cholesterol efflux
and reverse cholesterol transport make HDL a protective agent in inflammation-induced
organ damage including diabetes mellitus. However, inflammation and diabetes cause a
decrease in HDL-cholesterol concentrations and impair HDL function, placing HDL into the
centre of a vicious cycle that may escalate into diabetes mellitus, inflammation-induced
organ damage and atherosclerosis.
and reverse cholesterol transport make HDL a protective agent in inflammation-induced
organ damage including diabetes mellitus. However, inflammation and diabetes cause a
decrease in HDL-cholesterol concentrations and impair HDL function, placing HDL into the
centre of a vicious cycle that may escalate into diabetes mellitus, inflammation-induced
organ damage and atherosclerosis.
Summary
The protective properties of HDL in cytokine production, lipid oxidation, cholesterol efflux and reverse cholesterol transport make HDL a protective agent in inflammation-induced organ damage including diabetes mellitus. However, inflammation and diabetes cause a decrease in HDL-cholesterol concentrations and impair HDL function, placing HDL into the centre of a vicious cycle that may escalate into diabetes mellitus, inflammation-induced organ damage and atherosclerosis.
Lippincott Williams & Wilkins