Liver involvement is the most frequent extrarenal manifestation in autosomal-dominant
polycystic kidney disease (ADPKD). Liver cysts are responsible for most hepatic
complications, but other liver changes may occasionally be encountered, including
congenital hepatic fibrosis and segmental dilation of the biliary tract. Both molecular and
cellular changes implicated in liver cystogenesis have recently been enlightened by
advances in genetics of ADPKD and the development of genetically modified animal …