miR-15 and miR-16 induce apoptosis by targeting BCL2
Proceedings of the National Academy of Sciences, 2005•National Acad Sciences
Chronic lymphocytic leukemia (CLL) is the most common human leukemia and is
characterized by predominantly nondividing malignant B cells overexpressing the
antiapoptotic B cell lymphoma 2 (Bcl2) protein. miR-15a and miR-16-1 are deleted or down-
regulated in the majority of CLLs. Here, we demonstrate that miR-15a and miR-16-1
expression is inversely correlated to Bcl2 expression in CLL and that both microRNAs
negatively regulate Bcl2 at a posttranscriptional level. BCL2 repression by these microRNAs …
characterized by predominantly nondividing malignant B cells overexpressing the
antiapoptotic B cell lymphoma 2 (Bcl2) protein. miR-15a and miR-16-1 are deleted or down-
regulated in the majority of CLLs. Here, we demonstrate that miR-15a and miR-16-1
expression is inversely correlated to Bcl2 expression in CLL and that both microRNAs
negatively regulate Bcl2 at a posttranscriptional level. BCL2 repression by these microRNAs …
Chronic lymphocytic leukemia (CLL) is the most common human leukemia and is characterized by predominantly nondividing malignant B cells overexpressing the antiapoptotic B cell lymphoma 2 (Bcl2) protein. miR-15a and miR-16-1 are deleted or down-regulated in the majority of CLLs. Here, we demonstrate that miR-15a and miR-16-1 expression is inversely correlated to Bcl2 expression in CLL and that both microRNAs negatively regulate Bcl2 at a posttranscriptional level. BCL2 repression by these microRNAs induces apoptopsis in a leukemic cell line model. Therefore, miR-15 and miR-16 are natural antisense Bcl2 interactors that could be used for therapy of Bcl2-overexpressing tumors.
National Acad Sciences