[HTML][HTML] Mitochondrial H2O2 regulates the angiogenic phenotype via PTEN oxidation
KM Connor, S Subbaram, KJ Regan, KK Nelson… - Journal of Biological …, 2005 - ASBMB
Recent studies have demonstrated that the tumor suppressor PTEN (phosphatase and
tensin homolog deleted from chromosome 10), the antagonist of the phosphosphoinositol-3-
kinase (PI3K) signaling cascade, is susceptible to H 2 O 2-dependent oxidative inactivation.
This study describes the use of redox-engineered cell lines to identify PTEN as sensitive to
oxidative inactivation by mitochondrial H 2 O 2. Increases in the steady state production of
mitochondrial derived H 2 O 2, as a result of manganese superoxide dismutase (Sod2) …
tensin homolog deleted from chromosome 10), the antagonist of the phosphosphoinositol-3-
kinase (PI3K) signaling cascade, is susceptible to H 2 O 2-dependent oxidative inactivation.
This study describes the use of redox-engineered cell lines to identify PTEN as sensitive to
oxidative inactivation by mitochondrial H 2 O 2. Increases in the steady state production of
mitochondrial derived H 2 O 2, as a result of manganese superoxide dismutase (Sod2) …