[HTML][HTML] The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus: implications for PTEN stability to proteasome-mediated …
J Torres, R Pulido - Journal of Biological Chemistry, 2001 - ASBMB
The tumor suppressor phosphatase PTEN regulates cell migration, growth, and survival by
dephosphorylating phosphatidylinositol second messengers and signaling
phosphoproteins. PTEN possesses a C-terminal noncatalytic regulatory domain that
contains multiple putative phosphorylation sites, which could play an important role in the
control of its biological activity. The protein kinase CK2 phosphorylated, in a constitutive
manner, a cluster of Ser/Thr residues located at the PTEN C terminus. PTEN-phosphorylated …
dephosphorylating phosphatidylinositol second messengers and signaling
phosphoproteins. PTEN possesses a C-terminal noncatalytic regulatory domain that
contains multiple putative phosphorylation sites, which could play an important role in the
control of its biological activity. The protein kinase CK2 phosphorylated, in a constitutive
manner, a cluster of Ser/Thr residues located at the PTEN C terminus. PTEN-phosphorylated …