[HTML][HTML] Bcl-2 phosphorylation required for anti-apoptosis function
T Ito, X Deng, B Carr, WS May - Journal of Biological Chemistry, 1997 - ASBMB
The protooncogene Bcl-2 functions as a suppressor of apoptosis in growth factor-dependent
cells, but a post-receptor signaling mechanism is not known. We recently reported that
interleukin 3 (IL-3) and erythropoietin, or the protein kinase C activator bryostatin-1 (Bryo),
not only suppresses apoptosis but also stimulates the phosphorylation of Bcl-2 (May, WS,
Tyler, PG, Ito, T., Armstrong, DK, Qatsha, KA, and Davidson, NE (1994) J. Biol. Chem. 269,
26865–26870). To test whether phosphorylation is required for Bcl-2 function, conservative …
cells, but a post-receptor signaling mechanism is not known. We recently reported that
interleukin 3 (IL-3) and erythropoietin, or the protein kinase C activator bryostatin-1 (Bryo),
not only suppresses apoptosis but also stimulates the phosphorylation of Bcl-2 (May, WS,
Tyler, PG, Ito, T., Armstrong, DK, Qatsha, KA, and Davidson, NE (1994) J. Biol. Chem. 269,
26865–26870). To test whether phosphorylation is required for Bcl-2 function, conservative …