Increased TGF-β2 in severe asthma with eosinophilia
S Balzar, HW Chu, P Silkoff, M Cundall… - Journal of Allergy and …, 2005 - Elsevier
BACKGROUND: Airway eosinophilia and thickened subepithelial basement membrane
have previously been reported to increase with increases in TGF-β expression. However,
little is known regarding the expression of specific TGF-β isoforms (TGF-β1, TGF-β2, and
TGF-β3) in asthma, despite recent evidence suggesting that isoforms may have differing
biologic activities. OBJECTIVE: This study examined airway tissue expression of the 3 TGF-β
isoforms and several downstream pathway elements in 48 patients with severe asthma with …
have previously been reported to increase with increases in TGF-β expression. However,
little is known regarding the expression of specific TGF-β isoforms (TGF-β1, TGF-β2, and
TGF-β3) in asthma, despite recent evidence suggesting that isoforms may have differing
biologic activities. OBJECTIVE: This study examined airway tissue expression of the 3 TGF-β
isoforms and several downstream pathway elements in 48 patients with severe asthma with …