Biologic activities of IL-1 and its role in human disease
DM Essayan, CC Fox, F Levi-Schaffer, R Alam… - Journal of allergy and …, 1998 - Elsevier
The role of the polypeptide proinflammatory cytokine IL-1 family represents a group of
proteins that have contrasting and synergistic biologic responses. IL-1α and β and their
precursor forms are heavily involved in the enhancement of inflammation and host defense.
Within this family of gene products, there is also a naturally occurring receptor antagonist, IL-
1ra, as well as a family of receptor proteins that have differential signaling functions and
activities. The study of these proteins in human disease, including allergic disease and type …
proteins that have contrasting and synergistic biologic responses. IL-1α and β and their
precursor forms are heavily involved in the enhancement of inflammation and host defense.
Within this family of gene products, there is also a naturally occurring receptor antagonist, IL-
1ra, as well as a family of receptor proteins that have differential signaling functions and
activities. The study of these proteins in human disease, including allergic disease and type …