[PDF][PDF] The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses
G Trinchieri, S Pflanz, RA Kastelein - Immunity, 2003 - cell.com
G Trinchieri, S Pflanz, RA Kastelein
Immunity, 2003•cell.comOriginally the only known heterodimeric cytokine, IL-12 is now part of a family of five
cytokines and shares important functions in the regulation of both innate and adaptive
immunity with two of them, IL-23 and IL-27. Although initially these three cytokines were
considered to have largely overlapping immunological functions, more recent studies,
including two articles in this issue of Immunity (Hamano et al., 2003; Villarino et al., 2003),
indicate that they mediate complex and well-differentiated functions.
cytokines and shares important functions in the regulation of both innate and adaptive
immunity with two of them, IL-23 and IL-27. Although initially these three cytokines were
considered to have largely overlapping immunological functions, more recent studies,
including two articles in this issue of Immunity (Hamano et al., 2003; Villarino et al., 2003),
indicate that they mediate complex and well-differentiated functions.
Abstract
Originally the only known heterodimeric cytokine, IL-12 is now part of a family of five cytokines and shares important functions in the regulation of both innate and adaptive immunity with two of them, IL-23 and IL-27. Although initially these three cytokines were considered to have largely overlapping immunological functions, more recent studies, including two articles in this issue of Immunity (Hamano et al., 2003; Villarino et al., 2003), indicate that they mediate complex and well-differentiated functions.
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