Cytokine production in culture by cells isolated from the synovial membrane
FM Brennan, D Chantry, AM Jackson, RN Mainif… - T–Cell Activation in …, 1989 - Elsevier
Cytokine expression was investigated in synovial cell cultures isolated from diseased joints
of patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Tumour necrosis factor
alpha (TNFα) was produced spontaneously at high levels by both RA and OA synovial cells.
There was no correlation between cell composition and level of TNFα produced. In contrast,
lympbotoxin (LT) and Interferon gamma (IFNγ)(> 50 pg/ml) were not found. This was further
investigated in the RA cultures at both the mRNA and protein level. The results indicated that …
of patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Tumour necrosis factor
alpha (TNFα) was produced spontaneously at high levels by both RA and OA synovial cells.
There was no correlation between cell composition and level of TNFα produced. In contrast,
lympbotoxin (LT) and Interferon gamma (IFNγ)(> 50 pg/ml) were not found. This was further
investigated in the RA cultures at both the mRNA and protein level. The results indicated that …