A Lymphocyte-stimulating Factor produced in vitro
J Gordon, LD MacLean - Nature, 1965 - nature.com
J Gordon, LD MacLean
Nature, 1965•nature.comAbstract Bain, Vas and Lowenstein1 have recently reported that when peripheral leucocytes
of two individuals are cultured together, some of the cells enlarge and undergo mitosis. Bach
and Hirschhorn2 have further shown that not only intact cells, but also extracts of leucocytes,
disrupted by freezing and thawing, could stimulate cells to divide. Experiments reported in
this communication demonstrate that cell-free media obtained from leucocytes in culture
contain mitogenic factor (s), and suggest that these factors might be produced by the cells in …
of two individuals are cultured together, some of the cells enlarge and undergo mitosis. Bach
and Hirschhorn2 have further shown that not only intact cells, but also extracts of leucocytes,
disrupted by freezing and thawing, could stimulate cells to divide. Experiments reported in
this communication demonstrate that cell-free media obtained from leucocytes in culture
contain mitogenic factor (s), and suggest that these factors might be produced by the cells in …
Abstract
Bain, Vas and Lowenstein1 have recently reported that when peripheral leucocytes of two individuals are cultured together, some of the cells enlarge and undergo mitosis. Bach and Hirschhorn2 have further shown that not only intact cells, but also extracts of leucocytes, disrupted by freezing and thawing, could stimulate cells to divide. Experiments reported in this communication demonstrate that cell-free media obtained from leucocytes in culture contain mitogenic factor(s), and suggest that these factors might be produced by the cells in vitro.
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